中文名稱: 吡柔比星
英文名稱: Pirarubicin
英文別名: Pirarubicin [INN:JAN]; (2''R)-4'-O-Tetrahydropyranyladriamycin; (8S,10S)-10-((3-Amino-2,3,6-trideoxy-4-O-(2R-tetrahydro-2H-pyran-2-yl)-alpha-L-lyxo-hexopyranosyl)oxy)-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione; 1609RB; 4'-O-Tetrahydropyranyladriamycin; 4'-O-Tetrahydropyranyldoxorubicin; Pirarubicina; Pirarubicina [Spanish]; Pirarubicine; Pirarubicine [French]; Pirarubicinum; Pirarubicinum [Latin]; THP-adriamycin; 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-4-O-(tetrahydro-2H-pyran-2-yl)-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-; (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-4-O-[(2S)-tetrahydro-2H-pyran-2-yl]-alpha-L-lyxo-hexopyranoside; (3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-4-O-[(2R)-tetrahydro-2H-pyran-2-yl]-alpha-L-lyxo-hexopyranoside; Pirarubicin Hydrochloride
CAS號: 72496-41-4
分子式: C32H37NO12
分子量: 627.6357
分子結(jié)構(gòu):
密度: 1.51g/cm3
沸點: 834.7°C at 760 mmHg
閃點: 458.6°C
蒸汽壓: 1.51E-29mmHg at 25°C
性狀:為白色至淡黃色凍干疏松塊狀物
產(chǎn)品用途:抗腫瘤原料藥-細(xì)胞毒類藥物-作用于DNA化學(xué)結(jié)構(gòu)的藥物
能迅速進(jìn)入癌細(xì)胞,通過抑制核酸合成阻止細(xì)胞分裂,主要作用于G2期
對心臟、骨髓抑制的毒副作用較阿霉素小
生產(chǎn)方法:由阿霉素和二氫吡喃合成的蒽環(huán)類抗腫瘤抗生素。
儲運條件:存放在密封容器內(nèi),并放在陰涼,干燥處。2-8 ºC保存。
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