恩曲替尼 Entrectinib RXDX-101 1108743-60-7
Entrectinib (RXDX-101)是一種口服生物可利用的泛-TrkA/B/C,ROS1 和 ALK 抑制劑,IC50范圍為 0.1~1.7 nM。Phase 2。
恩曲替尼 Entrectinib RXDX-101 1108743-60-7
Entrectinib selectively blocks proliferation of ALK-dependent cell lines and potently inhibits ALK‐dependent signaling. Entrectinib also highly inhibits cell growth of the NSCLC cell line NCI‐H2228 bearing the EML4-ALK rearrangement.