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Acetylcysteine試劑返回列表頁(yè)

參考價(jià):￥400 - ￥600

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型號(hào)
HY-B0215
品牌
MCE
廠商性質(zhì)
代理商
所在地
杭州市

規(guī)格

500 mg 400元 10000可售

5 g 500元 10000可售

10 g 600元 10000可售

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Acetylcysteine試劑生物活性

NAC(防治)是一種黏液溶解的代理,減少粘液的厚度。NAC是一種活性氧抑制劑[1]。乙酰半cystine是一種半cystine前體,防止hemin-induced ferroptosis通過(guò)中和生成有毒的脂質(zhì)arachidonate-dependent 5-lipoxygenases活動(dòng)[5]。NAC誘發(fā)細(xì)胞凋亡[2][3]。NAC還具有抗流感病毒活動(dòng)

Acetylcysteine試劑IC₅₀ & Target

Human Endogenous Metabolite

體外研究
(In Vitro)

Acetylcysteine prevents apoptotic DNA fragmentation and maintains long-term survival in the absence of other trophic support in serum-deprived PC12 cells. Acetylcysteine also prevents death of PC12 cells and sympathetic neurons^[2].
Acetylcysteine causes dose-dependent reductions in viability in rat and human aortic smooth muscle cells^[3].
Acetylcysteine activates the Ras-extracellular signal-regulated kinase (ERK) pathway in PC12 cells. Acetylcysteine protects neuronal cells from death evoked by withdrawal of trophic support. Acetylcysteine increases nitric oxide (NO) release from protein-bound stores in vascular tissue. Acetylcysteine pretreatment of PC12 cells interferes with NGF-dependent signaling and neurite outgrowth, and it is suggested that Acetylcysteine interferes with redox-sensitive steps in the NGF mechanism^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

體內(nèi)研究
(In Vivo)

Acetylcysteine (150, 300 mg/kg) treatment significantly reduces liver transaminases in all groups of treatment, mostly in group Acetylcysteine 300. Lung glutathione peroxidase is significantly increases in group Acetylcysteine 300 (P=0.04), while the other oxidation biomarkers show no significant differences^[6].
Acetylcysteine improves cognition of 12-month-old SAMP8 mice in both the T-maze footshock avoidance paradigm and the lever press appetitive task without inducing non-specific effects on motor activity, motivation to avoid shock, or body weight^[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

163.19

性狀

Solid

Formula

C₅H₉NO₃S

CAS 號(hào)

616-91-1

中文名稱

結(jié)構(gòu)分類

Ketones, Aldehydes, Acids

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數(shù)據(jù)

In Vitro:

H₂O : 163 mg/mL (998.84 mM; ultrasonic and adjust pH to 7 with NaOH)

DMSO : ≥ 100 mg/mL (612.78 mM)

* "≥" means soluble, but saturation unknown.

配制儲(chǔ)備液

濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg

1 mM	6.1278 mL	30.6391 mL	61.2783 mL
5 mM	1.2256 mL	6.1278 mL	12.2557 mL
10 mM	0.6128 mL	3.0639 mL	6.1278 mL

請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 儲(chǔ)存時(shí)，請(qǐng)?jiān)?6 個(gè)月內(nèi)使用，-20°C 儲(chǔ)存時(shí)，請(qǐng)?jiān)?1 個(gè)月內(nèi)使用。

In Vivo:

請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥方式選擇適當(dāng)?shù)娜芙夥桨?。以下溶解方案都?qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液，再依次添加助溶劑：

——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的方式助溶